Fusion Software from S-Matrix® Corporation

Learning statistical experimental design and data modelling theories normally requires a lot of time and effort from the layman. However, without profound knowledge about this, conventional statistical software cannot be used correctly and effectively and errors are inevitable. In everyday business life, however, it is usually not possible to acquire the required depth and expertise on one's own and a statistician must be consulted for such tasks.

With the technology of S-Matrix, software solutions are offered by which even the statistical layman can create and evaluate DoE experiments by the click of a button.

Fusion QbD Software Platform - Lifecycle Software for the Development, Validation, and Transfer of Analytical Methods

Fusion QbD is a modular software platform providing bidirectional data exchange to various chromtography systems and complete CFR21 Part11 support.

The application of QbD principles is common in product development. Unique feature of the Fusion software is the configured application of these principles to the development of chromatographic methods. Traditionally, LC methods are mostly developed according to the OFAT (One Factor At a Time) principle. This approach is not only time consuming, but also suppresses the effect of interactions between the considered qualitative and quantitative effects. Only by examining all levels for all factors under consideration, one can gain a clear understanding of the contexts.

However, this approach would lead to immeasurably long series of experiments and is therefore hardly practicable. By applying Design of Experiments (DoE), these experiments can be reduced by a factor of 5 and still obtain a complete picture of all the effects of the considered chromatographic factors for the entire experimental region and get a quantitative statement for them.

Fusion QbD® is the only software for method development that uses the real and complete QbD package in line with ICH Q8(R2 ). All predictions are based on empirical models generated from experimental raw data, not theoretic "first principle" functions or in-house algorithms. This allows Fusion QbD to be applied to all separation methods: Chiral, HILIC, Ion Exchange, Size Exclusion, Normal Phase and, of course, Reverse Phase. Fusion QbD is also great for difficult sample matrix where classic baseline separation is not achieved.

Application Moduls 

Data Exchange Moduls 

Fusion QbD   Handout Fusion QbD

Fusion Pro Software - Pure DoE Software

Fusion Pro is an expert system standalone software which is completely aligned with Quality by Design principles, and designed for working scientists and engineers. The software provides a complete suite of Design of Experiments (DOE) technologies, including advanced data modeling and Monte Carlo simulation modeling capabilities, to support your R&D work within a simple workflow based work environment. Fusion Pro is the perfect Design of Experiments (DOE) software for formulation studies, Process Optimization, and Product Development, from initial screening through final optimization.

If you only need a DoE software without interface to a chromatography software and without regulatory framework, then Fusion Pro is the product of your choice. Fusion Pro is available as stand-alone software but also as a network solution.

Fusion Pro

Quotation Request

We would be pleased to make you an individual offer. The following information is required for this:

  • Fusion QbD or Fusion Pro?
  • Workstation or Network?
  • What chromatopgraphy system do you have?
  • Number of LC systems that should be supported
  • Number of users per application module

You can also use the request form: Quotation Request Form Fusion